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The cannabis plant contains at least 85 chemical compounds, known as cannabinoids, plus terpenes, which are aromatic oils that give the different varieties of cannabis their colour and taste. Cannabinoids and terpenes are secreted by the resin glands of the female cannabis plant.

Although THC and CBD are the most abundant and well-known cannabinoids, other cannabinoids like CBN, CBDV, THCV, CBG, CBC, THCA, and CBDA are set to have their moments in the spotlight as cannabis research becomes more expansive, with the results of this research more available to the public. These lesser known cannabinoids and terpenes play a crucial role in creating the “entourage effect”, while offering a host of therapeutic benefits individually. See Why Full Spectrum? for more information on the entourage effect.

THC (delta-9-tetrahydrocannabinol or Δ9-THC) is the most abundant cannabinoid and is also the primary psychoactive ingredient in cannabis. Without THC, there would be no “high”.  This is because THC mimics a neurotransmitter that naturally occurs in our brains called anandamide. Anandamide attaches to proteins in the brain called cannabinoid receptors, which then send signals related to pleasure, memory, thinking, perception, and coordination. In short, THC works by hijacking these natural cannabinoid receptors to create feelings of euphoria, relaxation, hyperesthesia and giddiness. Conversely, if taken in excess, it is THC that causes confusion, anxiety and paranoia. This is why proper dosing is vitally important to having a meaningful experience.

Along with being almost entirely responsible for your cerebral high, THC is also associated with a number of health benefits. Although cannabis science is in its infancy, with the full and specific benefits still being explored, existing research shows significant evidence that THC provides relief from chronic pain, increases appetite while reducing nausea, lessens muscle cramps and tremors, reduces inflammation, and aids sleep.

CBD (Cannabidiol), the second most abundant cannabinoid in the marijuana plant and the most abundant in the hemp plant, is believed to be largely responsible for cannabis’ therapeutic qualities. CBD is a completely non-psychoactive compound that has a major effect on the peripheral nervous and immune systems; it will not get you high.

CBD is the rising star in the health and wellness world, with the full scope if its potential benefits being explored by curious minds in science and medicine. Existing research shows significant evidence that CBD helps manage stress and anxiety, reduces pain and inflammation, improves sleep, increases mental clarity, benefits heart health, and treats seizure disorders. CBD is also great at reducing menstrual grumping and cramping.

Disclaimer:

This content is for educational purposes only. The information provided is derived from research gathered from external sources. Please view External Resources section below.

Full spectrum means that a product contains all the cannabinoids that are found in the cannabis plant in nature. This is important because the cannabis plant contains more than 85 cannabinoids plus terpenes that work in unison to create cannabis’ therapeutic outcomes. This synergy, known as “the entourage effect,” can only be experienced when we use the full spectrum of compounds found in the cannabis plant.

By combining compounds in their natural state, we exceed the sum of the parts and create a multiplying effect which produces a more meaningful experience compared to any one of the compounds used in isolation.  This is why cannabis edibles made with only isolate, even at high doses, are less potent and less beneficial than full spectrum preparations.

Disclaimer:

This content is for educational purposes only. The information provided is derived from research gathered from external sources. Please view External Resources section below.

Bioavailability is defined as “The degree to which a drug or other substance becomes available to the target tissue after administration”—The American Heritage Medical Dictionary.

In the interests of clarity and relevance, we will be exploring the bioavailability of orally ingested cannabinoids. Perhaps the most critical factor influencing the potency of orally ingested cannabis is bioavailability. Simply put, the more bioavailable the edible is, the less you will need to consume to experience meaningful effects. High bioavailability is what sets Rosebud Remedy’s edibles apart. Every step of our research and development was grounded in the understanding that high bioavailability would mean a high-quality result.

Rosebud uses both organic, unrefined coconut oil and Fractionated MCT Oil (please see the Fractionated MCT Oil tab below) in its products. This is because recent studies have shown that the presence of vegetable oil increases the bioavailability of both CBD and THC. Also, further experiments have shown that CBD and THC have a very high affinity to the so-called chylomicrons – particles produced in the small intestine that transport the lipids from the small intestine to the bloodstream via the lymphatic system, bypassing the liver.  Bypassing the liver eliminates the “first-pass effect”, whereby the liver effectively prevents the absorption of many psychoactive compounds.

Another way to increase bioavailability in edibles is through the use of lecithin. When added to cannabis, lecithin increases absorption of THC and other cannabinoids into your cell membranes and speeds up the process. It doesn’t technically make your oil “more potent,” but the effects will come on faster and will feel stronger.  Furthermore, lecithin also serves as a surfactant (a compound that lowers surface tension), meaning that lecithin helps to distribute THC and cannabinoids more efficiently.

For these reasons Rosebud uses sunflower lecithin in both its candies and drops.

Disclaimer:

This content is for educational purposes only. The information provided is derived from research gathered from external sources. Please view External Resources section below.

Every bag of gummies comes with a Batch #. This number is linked to the production, packaging, and lab results of each batch. This allows for radical transparency for you, our customers. This information is available upon request; just click on the contact link and provide us your batch #, and the information will be sent via email within two business days.

At Rosebud, we take quality assurance seriously. The Batch #’s also allow us to address any issues that may arise post-production. Doing this demands the highest level of accountability from Rosebud in terms of QA procedures, food safety and efficacy.

Fractionated MCT oil is the most efficient carrier oil for cannabinoids because, unlike other fat molecules that require a complex process of digestion, MCTs are rapidly metabolized and absorbed into the bloodstream, putting the cannabinoid to use quickly.  With effects being felt in as little as 30 minutes, users can accurately “dial in their dose.” Precise dosing dramatically reduces the risk of taking too much or greening out, making the experience safe, effective and enjoyable for both recreational and medicinal uses. Additionally, studies have found that MCT oil can assist with energy, brain function, weight management, and gut health.

Disclaimer:

This content is for educational purposes only. The information provided is derived from research gathered from external sources. Please view External Resources section below.

1. Pharmacokinetics of cannabinoids. – PubMed- NCBI
2. Kubala, J. (2018, February 26). 7 Benefits and Uses of CBD Oil (Plus Side Effects).
3. CBD- Cannabidiol. (2019, November 15).
4. Branford A. (2017, May 18) What is THC
5. Bioavailability: The Story Of How Cannabis Enters The Body. (2019, August 27).
6. Dr inż. Beata Plutowska, Cannabinoids – can you stomach them? How to increase the bioavailability

Disclaimer:

This content is for educational purposes only. The information provided is derived from research gathered from external sources.